SSYLIA支架置入术治疗症状性椎动脉或

背景和目标症状性颅内动脉狭窄患者药物治疗的卒中发生率高达每年10%-24%。这项多中心、非随机、前瞻性可行性研究评估了NEUROLINK系统治疗脊椎或颅内动脉狭窄的效果。方法患者年龄为18-80岁，其症状可归因于≥50%狭窄的单一目标血管病变。患者在术前、术后1年内接受了5次神经系统功能检查，6个月时接受了血管造影检查。结果在招募的61名患者中，对43条（70.5%）颅内动脉（15条颈动脉、5条大脑中动脉、1条大脑后动脉、17条基底动脉、5条椎动脉）和18条（29.5%）颅外椎动脉（6条口动脉，12条后下小脑动脉近端[PICA]）进行了治疗。在前30天内，4名（6.6%）患者发生卒中，没有死亡病例。61名患者中，58名（95%）成功地植入了支架。6个月时，12/37（32.4%)的颅内动脉和6/14（42.9%）颅外椎动脉，以及4条椎口动脉出现50%的狭窄。7例（39%）的复发性狭窄是有症状的。30天后，55名患者中4名发生卒中，其中1名是唯一一例未植入支架的患者。结论NEUROLINK系统与支架植入的高成功率相关。30天内6.6%的患者发生卒中，30天至1年内7.3%的患者发生卒中。尽管35%的患者发生了再狭窄，但其中61%是无症状的。需要开展使用NEUROLINK系统的更多试验。参考文献：InvestigatorsSS.SSYLIA:Stentingofsymptomaticatheroscleroticlesionsinthevertebralorintracranialarteries(SSYLVIA)studyresults.Stroke;35:-.原文：SSYLIA:Stentingofsymptomaticatheroscleroticlesionsinthevertebralorintracranialarteries(SSYLVIA)studyresultsBACKGROUNDandPURPOSEStrokeratesinpatientswithsymptomaticintracranialstenosismaybeashighas10%to24%peryearonmedicaltherapy.Thismulticenter,nonrandomized,prospectivefeasibilitystudyevaluatedtheNEUROLINKSystemfortreatmentofvertebralorintracranialarterystenosis.METHODSPatientswere18to80yearsoldwithsymptomsattributedtoasingletargetlesionof≥50%stenosis.Patientsreceived5neurologicalexaminationsbeforeandintheyearaftertheprocedure,andanotherangiogramat6months.RESULTSIn61patientsenrolled,43(70.5%)intracranialarteries(15internalcarotid,5middlecerebral,1posteriorcerebral,17basilar,5vertebral)and18(29.5%)extracranialvertebralarteries(6ostia,12proximaltotheposteriorinferiorcerebellarartery[PICA])weretreated.Inthefirst30days,4patients(6.6%)hadstrokesandnodeathsoccurred.Successfulstentplacementwasachievedin58/61cases(95%).At6months,stenosisof50%occurredin12/37(32.4%)intracranialarteriesand6/14(42.9%)extracranialvertebrals,4inthevertebralostia.Seven(39%)recurrentstenosesweresymptomatic.Fourof55patients(7.3%)hadstrokeslaterthan30days,1ofwhichwasintheonlypatientnotstented.CONCLUSIONSTheNEUROLINKSystemisassociatedwithahighrateofsuccessfulstentdeployment.Strokesoccurredin6.6%ofpatientswithin30daysandin7.3%between30daysand1year.Althoughrestenosesoccurredin35%ofpatients,61%wereasymptomatic.FurthertrialsinvolvingtheNEUROLINKSystemarewarranted.REFERENCE:InvestigatorsSS.SSYLIA:Stentingofsymptomaticatheroscleroticlesionsinthevertebralorintracranialarteries(SSYLVIA)studyresults.Stroke;35:-.







































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